Differential diagnosis of parkinsonism with [18F]fluorodeoxyglucose and PET
Identifieur interne : 001F07 ( Main/Exploration ); précédent : 001F06; suivant : 001F08Differential diagnosis of parkinsonism with [18F]fluorodeoxyglucose and PET
Auteurs : Angelo Antonini [États-Unis] ; Ken Kazumata [États-Unis] ; Andrew Feigin [États-Unis] ; Francine Mandel [États-Unis] ; Vijay Dhawan [États-Unis] ; Claude Margouleff [États-Unis] ; Eidelberg [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1998-03.
English descriptors
- KwdEn :
Abstract
The clinical differentiation between typical idiopathic Parkinson's disease (IPD) and atypical parkinsonian disorders (APD) is complicated by the presence of signs and symptoms common to both forms of parkinsonism. Metabolic brain imaging with [18F]fluorodeoxyglucose (FDG) and positron emission tomography (PET) may be a useful adjunct in differentiating APD from IPD. To explore this possibility, we studied 48 parkinsonian patients suspected as having possible APD because of a deteriorating response to dopaminergic treatment, the development of autonomic dysfunction, or both. A group of 56 patients with likely IPD served as control subjects. We used quantitative FDG/PET to measure regional rates of cerebral glucose use in IPD and APD patients. We used discriminant analysis to categorize IPD and APD patients based on their regional metabolic data. We found that a linear combination of caudate, lentiform, and thalamic values accurately discriminated APD from IPD patients (p < 0.0001). Significant metabolic abnormalities were present in the striatum and the thalamus of 36 of 48 (75%) APD patients. Our findings show that measurements of regional glucose metabolism can be used to discriminate patients with suspected APD from their counterparts with classic IPD. FDG/PET may be a useful adjunct to the clinical examination in the differential diagnosis of parkinsonism.
Url:
DOI: 10.1002/mds.870130212
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential diagnosis of parkinsonism with [18F]fluorodeoxyglucose and PET</title><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name></author><author><name sortKey="Kazumata, Ken" sort="Kazumata, Ken" uniqKey="Kazumata K" first="Ken" last="Kazumata">Ken Kazumata</name></author><author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name></author><author><name sortKey="Mandel, Francine" sort="Mandel, Francine" uniqKey="Mandel F" first="Francine" last="Mandel">Francine Mandel</name></author><author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name></author><author><name sortKey="Margouleff, Claude" sort="Margouleff, Claude" uniqKey="Margouleff C" first="Claude" last="Margouleff">Claude Margouleff</name></author><author><name sortKey="Eidelberg" sort="Eidelberg" uniqKey="Eidelberg" last="Eidelberg">Eidelberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5D101E872AAA841676D06C193DF7CDC6DD0D3CE7</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1002/mds.870130212</idno><idno type="url">https://api.istex.fr/document/5D101E872AAA841676D06C193DF7CDC6DD0D3CE7/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002576</idno><idno type="wicri:Area/Main/Curation">002240</idno><idno type="wicri:Area/Main/Exploration">001F07</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Differential diagnosis of parkinsonism with [18F]fluorodeoxyglucose and PET</title><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Movement Disorders Center and Functional Brain Imaging Laboratory, Department of Neurology, North Shore University Hospital, Manhasset, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kazumata, Ken" sort="Kazumata, Ken" uniqKey="Kazumata K" first="Ken" last="Kazumata">Ken Kazumata</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Movement Disorders Center and Functional Brain Imaging Laboratory, Department of Neurology, North Shore University Hospital, Manhasset, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Movement Disorders Center and Functional Brain Imaging Laboratory, Department of Neurology, North Shore University Hospital, Manhasset, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mandel, Francine" sort="Mandel, Francine" uniqKey="Mandel F" first="Francine" last="Mandel">Francine Mandel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Medicine and Research, North Shore University Hospital, Manhasset, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Movement Disorders Center and Functional Brain Imaging Laboratory, Department of Neurology, North Shore University Hospital, Manhasset, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Margouleff, Claude" sort="Margouleff, Claude" uniqKey="Margouleff C" first="Claude" last="Margouleff">Claude Margouleff</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Movement Disorders Center and Functional Brain Imaging Laboratory, Department of Neurology, North Shore University Hospital, Manhasset, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Eidelberg" sort="Eidelberg" uniqKey="Eidelberg" last="Eidelberg">Eidelberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Movement Disorders Center and Functional Brain Imaging Laboratory, Department of Neurology, North Shore University Hospital, Manhasset, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1998-03">1998-03</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="268">268</biblScope><biblScope unit="page" to="274">274</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5D101E872AAA841676D06C193DF7CDC6DD0D3CE7</idno><idno type="DOI">10.1002/mds.870130212</idno><idno type="ArticleID">MDS870130212</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atypical parkinsonism</term><term>Multiple system atrophy</term><term>Parkinson's disease</term><term>Positron emission tomography</term><term>[18F]Fluorodeoxyglucose</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The clinical differentiation between typical idiopathic Parkinson's disease (IPD) and atypical parkinsonian disorders (APD) is complicated by the presence of signs and symptoms common to both forms of parkinsonism. Metabolic brain imaging with [18F]fluorodeoxyglucose (FDG) and positron emission tomography (PET) may be a useful adjunct in differentiating APD from IPD. To explore this possibility, we studied 48 parkinsonian patients suspected as having possible APD because of a deteriorating response to dopaminergic treatment, the development of autonomic dysfunction, or both. A group of 56 patients with likely IPD served as control subjects. We used quantitative FDG/PET to measure regional rates of cerebral glucose use in IPD and APD patients. We used discriminant analysis to categorize IPD and APD patients based on their regional metabolic data. We found that a linear combination of caudate, lentiform, and thalamic values accurately discriminated APD from IPD patients (p < 0.0001). Significant metabolic abnormalities were present in the striatum and the thalamus of 36 of 48 (75%) APD patients. Our findings show that measurements of regional glucose metabolism can be used to discriminate patients with suspected APD from their counterparts with classic IPD. FDG/PET may be a useful adjunct to the clinical examination in the differential diagnosis of parkinsonism.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name></region><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name><name sortKey="Eidelberg" sort="Eidelberg" uniqKey="Eidelberg" last="Eidelberg">Eidelberg</name><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name><name sortKey="Kazumata, Ken" sort="Kazumata, Ken" uniqKey="Kazumata K" first="Ken" last="Kazumata">Ken Kazumata</name><name sortKey="Mandel, Francine" sort="Mandel, Francine" uniqKey="Mandel F" first="Francine" last="Mandel">Francine Mandel</name><name sortKey="Margouleff, Claude" sort="Margouleff, Claude" uniqKey="Margouleff C" first="Claude" last="Margouleff">Claude Margouleff</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F07 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001F07 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:5D101E872AAA841676D06C193DF7CDC6DD0D3CE7
|texte= Differential diagnosis of parkinsonism with [18F]fluorodeoxyglucose and PET
}}
| This area was generated with Dilib version V0.6.23. |  |